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So, even though some of the bacteria are destroyed in the vacuole that feeds the MHC class II pathway of antigen demonstration with the induction of helper T cells, others survive by escaping in to the cytosol of the cell. This is important because the antigen-processing pathway that feeds antigenic peptides to the surface of the cell for recognition by killer T cells is certainly generated in this cellular compartment. ‘We reasoned that if we’re able to get Listeria to secrete a foreign protein into the interior of the cell, it could target that pathway and would elicit a solid killer T cell response, and we have shown that,’ says Paterson.